Artificial Pancreas Trondheim

Most recent publications:

Ahdab, M., Benam, K. D., Khoshamadi, H., Fougner, A. L., and Gros, S., Sensor Fusion for Glucose Monitoring Systems, 22nd IFAC World Congress, Yokohama, Japan, July 2023, to be presented.

Langholz, J., Benam, K. D., Sharan, B., Gros, S., and Fougner, A. L., Fully Automated Bi-Hormonal Intraperitoneal Artificial Pancreas Using a Two-Layer PID Control Scheme, European Control Conference (ECC), Bucharest, Romania, June 2023, to be presented.

Carlsen, S. M., and Christiansen, S. C., Effects of Low-Dose Glucagon on Subcutaneous Insulin Absorption in Pigs (ePoster), ATTD 2023, Berlin, Germany, Feb 2023.

Patil, P., Lema-Pérez, L., Siddiqui, S. I., Stavdahl, Ø., and Fougner, A. L., Electrocardiogram as a Predictor for Early and Robust Meal Onset Detection in Artificial Pancreas (ePoster), ATTD 2023, Berlin, Germany, Feb 2023.

Benam, K. D., Khoshamadi, H., Åm, M. K., Stavdahl, Ø., Gros, S., and Fougner, A. L., Identifiable Prediction Animal Model for the Bi-hormonal Intraperitoneal Artificial Pancreas, Journal of Process Control, Vol. 121, pp. 13–29, Jan 2023.

Halvorsen, M., Benam, K. D., Khoshamadi, H., and Fougner, A. L., Blood Glucose Level Prediction Using Subcutaneous Sensors for in Vivo Study: Compensation for Measurement Method Slow Dynamics Using a Kalman Filter Approach, IEEE Conference on Decision and Control 2022, Cancún, Mexico, 6–9 Dec 2022.

Teigen, I. A., Åm, M. K., Riaz, M., Christiansen, S. C., and Carlsen, S. M., Vasodilatory effects of glucagon: A possible new approach to improve subcutaneous insulin absorption in artificial pancreas devices, Frontiers in Bioengeneering and Biotechnology, No. 986858, Vol. 10, Sep 2022.

Åm, M. K., Teigen ,I. A., Carlsen, S. M., and Christiansen, S. C., Severe bradycardia and hypotension in anaesthetized pigs: Possible interaction between octreotide, xylazine, and atropine: A case series, Scandinavian Journal of Laboratory Animal Sciences, in press.

Benam, K. D., Khoshamadi, H., Lema-Pérez, L., Gros, S., and Fougner, A. L., A Nonlinear State Observer for the Bi-Hormonal Intraperitoneal Artificial Pancreas, Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) 2022, Glasgow, Jul 2022.

Åm, M. K., Munkerud, E. Y., Berge, M. H., Christiansen, S. C., and Carlsen, S. M., The Effect of Glucagon on Local Subcutanous Blood Flow in Non-Diabetic Volunteers; A Proof-of-Concept Study, European Journal of Pharmacology, No. 175045, Vol. 926, Jul 2022.

Schwermer, S. F., Near Infrared Spectroscopy for Continuous Glucose Monitoring, ISBN ISBN 978-82-326-5518-2, in: Doctoral theses at NTNU (ISSN 1503-8181), 2022:184, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Jun 2022.

More publications:

— List of APT's publications 2014–present.

— List of older publications and patents by APT members.

— A list of all scientific publications from the APT group can be found in Cristin.

Former employees of the APT research group:
	Dr Salman Ijaz Siddiqui was a postdoc at Dept. of Electronic Systems from March 2020 to August 2022. He finished his PhD at NTNU in Nov 2019 and his work in APT was related to our "Listening to the patients" project and early detection of meal onset. His research interests included acoustic signal processing and acoustic underwater communications.
	Silje Fuglerud Schwermer (Silje Skeide Fuglerud) received her MSc degree in Applied Physics from NTNU in 2016, with a specialization in biophysical applications of optics and microfluidics. She wrote her MSc thesis on “Evanescent light field trapping and transport of micro- and nanocrystals of biological macromolecules on a waveguide for serial crystallography” at Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany. From 2017 to 2022, Silje was a PhD candidate with APT and worked with methods for optical spectroscopy and sensor fusion. Funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU). Her PhD thesis is entitled Near Infrared Spectroscopy for Continuous Glucose Monitoring and the public defense was in June 2022. Supervised by Dag Roar Hjelme and Astrid Aksnes.
	Dr Ilze Dirnena-Fusini received her MSc degree in Natural Science at University of Latvia in 2012. She completed her studies at Paul Stradins Health and Social Care College, where she received education in internal medicine and attained the diploma of Biomedical Laboratory Assistant. She worked as a PhD candidate for APT from February 2016 until Spring 2021. Her PhD thesis is entitled Intraperitoneal insulin administration – superior choice for an artificial pancreas? and the public defense was in Oct 2021. Supervised by Sverre Christiansen, Sven Magnus Carlsen and Anders Lyngvi Fougner.
	Dr Ine Larsen Jernelv received her MSc degree in Nanotechnology from NTNU in 2015 and worked for APT as a PhD candidate from May 2016 until April 2020. Her PhD thesis is entitled "Mid-Infrared Tuneable Laser Spectroscopy for Glucose Sensing" and the public defense was in Aug 2020. Supervised by Astrid Aksnes. Currently employed as a researcher at the University of Tromsø -- The Arctic University of Norway.
	Dr Telagam Setti Sunilkumar was an ERCIM postdoctoral research fellow at the Department Engineering Cybernetics. He received his Ph.D. in Electrical Engineering from the Indian Institute of Technology Indore. His research areas are digital signal processing and machine learning. He was employed as a postdoc in Artificial Pancreas Trondheim from February 2019 to April 2020. His focus was on early meal onset detection in diabetes. Supervised by Anders Lyngvi Fougner and Øyvind Stavdahl.
	Dr Claudia Lopez Zazueta was an ERCIM postdoctoral research fellow at the Department Engineering Cybernetics. MSc in Physics and Mathematics (University of Granada, Spain), with specialization in Mathematical Methods and Models in Science and Engineering, and MSc in Mathematical Sciences (UNAM, Mexico). PhD in Control, Signal and Image Processing (Inria, France). Employed as a postdoc in Artificial Pancreas Trondheim from February 2019 to November 2019, focusing on mathematical modeling and system identification. Supervised by Anders Lyngvi Fougner and Øyvind Stavdahl. Currently (Nov 2021) working as a postdoc in INRA, Jouy-en-Josas, France.
	Dr Karolina Milenko was a postdoctoral research fellow at Department of Electronic Systems, NTNU. MSc and PhD in Physics, with specialization in optical fiber sensing technologies. Employed as a postdoc in Artificial Pancreas Trondheim from June 2016 to November 2019, she focused on design and development of novel sensing devices for intraperitoneal glucose levels, based on optical spectroscopy methods. Supervised by Astrid Aksnes. Currently (Nov 2021) working in SINTEF Digital, Oslo.
	Odd Martin Staal did an industrial PhD with Prediktor Instruments (former Prediktor Medical) and APT/NTNU from 2015 to 2018. His PhD thesis is entitled "Blood glucose dynamics: Identification, smoothing and real time estimation in free-living settings and the public defense was in May 2019. Supervised by Øyvind Stavdahl, Steinar Sælid, Anders L. Fougner and Sven M. Carlsen. Previous experience included a MSc in Engineering Cybernetics (2006), 2 years experience from the Norwegian Defence Research Establishment and 6.5 years experience from medical device development in Axis-Shield PoC.
	Dr Konstanze Kölle received her MSc degree in Chemical Engineering at RWTH Aachen University and worked for APT as a PhD candidate from May 2014 until September 2018. Her PhD thesis is entitled "Towards a Safe Artificial Pancreas: Meal Detection and the Intraperitoneal Route" and the public defence was 7 Dec 2018. The main supervisor was Associate Professor Øyvind Stavdahl and the co-supervisors were Professor Sven M. Carlsen and Associate Professor Anders Fougner. Currently (Nov 2021) working in SINTEF Energy Research, Trondheim.

Former students and interns of the APT research group:
	Petter Skau-Nilsen pursued his MSc thesis at Dept. of Engineering Cybernetics during Spring 2022. His project was related to estimation of glucose absorption. Supervised by Anders Lyngvi Fougner, Karim Davari Benam and Hasti Khoshamadi.
	Markus Holt pursued his term project and MSc thesis at Dept. of Engineering Cybernetics during Fall 2021 and Spring 2022. His topic was related to modelling of how exercise is affecting glucose level in people with diabetes. Supervised by Anders Lyngvi Fougner and Hasti Khoshamadi.
	Martha Halvorsen pursued her term project and MSc thesis at Dept. of Engineering Cybernetics during Fall 2021 and Spring 2022. Her project was related to blood glucose level estimation. Supervised by Anders Lyngvi Fougner, Karim Davari Benam and Hasti Khoshamadi.
	Åshild Rindal was a 5th year Medicine student at NTNU and pursued her thesis at Dept of Clinical and Molecular Medicine during Fall 2021 and Spring 2022, on a project related to glucagon. Supervised by Sven Carlsen and Sverre Chr Christiansen.
	Eirik Jakobsen Daltveit pursued his term project at Dept. of Engineering Cybernetics during Fall 2021 and Spring 2022. His project was related to blood glucose level estimation. Supervised by Anders Lyngvi Fougner, Karim Davari Benam and Hasti Khoshamadi.
	Christian Lillestrand pursued his term project at Dept. of Engineering Cybernetics during Fall 2021 and Spring 2022. His project was related to mathematical modelling of glucose absorption after meals. Supervised by Anders Lyngvi Fougner, Karim Davari Benam and Hasti Khoshamadi.
	Anette Fagerheim Bjerke pursued her term project and MSc thesis at Dept. of Electronic Systems during Fall 2021 and Spring 2022. Her project was related to meal detection. Supervised by Tor Andre Myrvoll, Salman Siddiqui and Anders Fougner.
	Davis Guntars Klavins pursued his term project and MSc thesis at Dept. of Electronic Systems during Fall 2021 and Spring 2022. His topic was related to meal detection. Supervised by Dag Roar Hjelme, Salman Siddiqui and Anders Fougner.
	Ahmed Khalil Omar Isifan pursues his term project and MSc thesis at Dept. of Electronic Systems during Fall 2021 and Spring 2022. His topic was related to audio processing. Supervised by Dag Roar Hjelme, Salman Siddiqui and Anders Fougner.
	Khadija Laajab pursues her term project and MSc thesis at Dept. of Electronic Systems during Fall 2021 and Spring 2022. Her topics were related to covid-19 detection and meal detection. Supervised by Dag Roar Hjelme, Salman Siddiqui and Anders Fougner.
	Ares Tahiraga was an exchance student from Technische Universität Kaiserslautern and pursued his term project at Dept. of Electronic Systems during Fall 2021. His topic was related to covid-19 detection. Supervised by Peter Svensson and Salman Siddiqui.
	Jacob Hemstad Gimle pursued his term project at Dept. of Engineering Cybernetics during Fall 2021. His topic was related to covid-19 detection. Supervised by Anders Lyngvi Fougner and Salman Siddiqui.
	Patrick Bösch, our Development Engineer, was also a part-time MSc student at Dept. of Engineering Cybernetics and pursued his term project and MSc thesis during Fall 2020 and Spring 2021, on a topic related to insulin absorption. Supervised by Øyvind Stavdahl and Anders Lyngvi Fougner.
	Eira Mørch-Thoresen pursued her term project and MSc thesis at Dept. of Engineering Cybernetics during Fall 2020 and Spring 2021, on projects related to modeling how physical activity and meals affect the glucose-insulin regulatory system. Supervised by Anders Lyngvi Fougner and Hasti Khoshamadi.
	Mai Ve Bugge pursued her term project and MSc thesis at Dept. of Engineering Cybernetics during Fall 2020 and Spring 2021, on a project related to model based glucose control, in collaboration with DTU. Supervised by Anders Lyngvi Fougner, Karim Davari Benam, John Bagterp Jørgensen and Dimitri Boiroux.
	Mads Wikmark Formo pursued his term project and MSc thesis at Dept. of Engineering Cybernetics during Fall 2020 and Spring 2021, on projects related to safety and reliability in medical equipment. Supervised by Anders Lyngvi Fougner and Mary Ann Lundteigen.
	Erlend Yttersian Munkerud was a 5th year Medicine student at NTNU and pursued his thesis at Dept of Clinical and Molecular Medicine during Spring 2021, on a project related to increasing the absorption of drugs. Supervised by Sven Carlsen and Sverre Chr Christiansen.
	Mathilde Hallem Berge was a 5th year Medicine student at NTNU and pursued her thesis at Dept of Clinical and Molecular Medicine during Spring 2021, on a project related to increasing the absorption of drugs. Supervised by Sven Carlsen and Sverre Chr Christiansen.
	Viljar Grimstad Bliksvær pursued his MSc thesis at Dept. of Engineering Cybernetics during Spring 2021, on a project related to noninvasive sensors and machine learning. Supervised by Anders Lyngvi Fougner and Pallavi Patil.
	Céline Angonin pursued her term project and MSc thesis at Dept. of Electronic Systems during Fall 2020 and Spring 2021, on a project related to acoustic signal processing. Supervised by Salman Siddiqui and Dag Roar Hjelme.
	Ådne Skjelbreid Djuve pursued his MSc thesis at Dept. of Engineering Cybernetics during Spring 2021, on a project related to acoustic signals and machine learning. Supervised by Salman Siddiqui, Anders Fougner and Pierluigi Salvo Rossi.
	Miriam Kopperstad Wolff pursued her term project and MSc thesis at Troll Labs (in Dept. of Mechanical and Industrial Engineering) during Fall 2020 and Spring 2021. Her thesis was entitled "Comparison of Various Insulin Pumps with Respect to Accuracy of the Insulin Delivery." Supervised by Martin Steinert and Anders Lyngvi Fougner.
	Erling Solberg pursued his term project at Dept. og Electronic Systems during fall 2020, on a project related to mid-infrared spectroscopy. Supervised by Dag Roar Hjelme.
	Sigurd Heide Rosland pursued a term project and MSc thesis at Dept. of Engineering Cybernetics during Fall 2019 and Spring 2020, on sensor and pump interface for closed-loop glucose control experiments. Supervised by Anders Lyngvi Fougner, Patrick Bösch and Øyvind Stavdahl.
	Andrea Holten pursued a term project and a MSc thesis at Dept. of Engineering Cybernetics during Fall 2019 and Spring 2020. Thesis title "Enhancing the robustness of meal onset detection by sensor fusion". Supervised by Anders Lyngvi Fougner and Sunilkumar Telagam Setti.
	Nora Lyngstad Røste pursued a term project and a MSc thesis at Dept. of Engineering Cybernetics during Fall 2019 and Spring 2020. Thesis title "Analysis of repetitive electrograms". Supervised by Anders Lyngvi Fougner, Øyvind Stavdahl and Sunilkumar Telagam Setti.
	Emil Jenssen, Martin Navarsete Murvold and Henriette Mathisen pursued their BSc theses at Dept. of Engineering Cybernetics during Spring 2020, on a project related to miniaturization of a hormone infusion system. Supervised by Patrick Bösch.
	Ludvig S. Sæle pursued a term project at Dept. of Engineering Cybernetics during Spring 2019 on a topic related to bowel sounds, and his MSc thesis during Fall 2019 on a topic related to parametric uncertainty in model-based control. Supervised by Anders Lyngvi Fougner and Sebastien Gros.
	Tamara Gini, BSc in Computer Science from ETH Zürich. She was with APT for 3 months (Sep-Dec 2019) as part of an IAESTE internship. She worked on the interface between glucose sensors, insulin pumps and a control algorithm, as well as helping with other tasks in APT requiring excellent programming skills.
	Chris Arun Muralitharan pursued a term project at Dept. of Engineering Cybernetics during Fall 2019, on Kalman filter for sensor fusion in biomedical applications. Supervised by Anders Lyngvi Fougner.
	Waleed Azam pursues his MSc at Dept. of Electronic Systems and worked for APT in a 15% position during Spring and Summer 2019. His work consisted of programming tasks, which focus on interfacing experimental hardware with advanced control software.
	Elise Søiland pursued a term project and her MSc thesis at Dept. of Engineering Cybernetics during Fall 2018 and Spring 2019, on topics related to system identification and meal detection. Supervised by Anders Lyngvi Fougner.
	Peter Martinius Stige pursued a term project and his MSc thesis at Dept. of Engineering Cybernetics during Fall 2018 and Spring 2019, on topics related to Prediktor Medical AS. Supervised by Anders Lyngvi Fougner and Steinar Sælid.
	Karina Strøm pursued her MSc thesis at Dept. of Electronic Systems during Spring 2019, on a topic related to optical glucose sensors. Supervised by Astrid Aksnes and Ine Larsen Jernelv.
	Andreas Grue Thorbjørnsrud pursued his MSc in Pharmacy at Department of Clinical and Molecular Medicine during Fall 2018 and Spring 2019. He performed a literature review on ways to enhance the absorption of drugs. Supervised by Sven M. Carlsen.
	Solveig Nyland Finne pursued her MSc in Pharmacy at Department of Clinical and Molecular Medicine during Fall 2018 and Spring 2019. She studied ways of enhancing the absorption of drugs. Supervised by Sven M. Carlsen.
	Ørjan Halvorsen pursued a term project at Dept. of Electronic Systems during Fall 2018, on a topic related to exploring nanopatterns for use in a optical sensor based on surface enhanced Raman Scattering. Supervised by Karolina Milenko.
	Eduardo Pelizzari Raizel da Cruz stayed with the Dept. of Electronic Systems and APT during Fall 2018 during an IAESTE internship. He is a senior year Electrical Engineering major student at Western Paraná State University, Brasil. His previous work focused on sensor programming, signal processing, tests and measurements. He worked on data logging and implementation of real-time glucose prediction in the lab. Supervised by Silje S. Fuglerud.
	Mathias Sunde Zakariassen pursued his MSc thesis at Dept. of Mechanical and Industrial Engineering during Spring 2018, on a topic related to APT and development of an intraperitoneal port. Supervised by Terje Rølvåg.
	Karoline Holst Hopland pursued her MSc thesis at Dept. of Mechanical and Industrial Engineering during Spring 2018, on a topic related to APT and development of an intraperitoneal port. Supervised by Terje Rølvåg.
	Snorre Braathen Kjeldby pursued his MSc thesis at Dept. of Electronic Systems during Spring 2018, on a topic related to APT and optical spectroscopy methods for glucose sensing. Supervised by Karolina Milenko, Astrid Aksnes, Dag Roar Hjelme and Reinold Ellingsen.
	Kaja Kvello pursued her MSc thesis at Dept. of Engineering Cybernetics during Spring 2018, on a topic related to APT and meal detection. Supervised by Konstanze Kölle and Anders Fougner.
	Karl Arthur Unstad pursued his MSc thesis at Dept. of Engineering Cybernetics during Winter 2017/2018, on a topic related to APT and fault detection. Supervised by Konstanze Kölle, Anders Fougner and Øyvind Stavdahl.
	Stephan Ihle, MSc in Electrical Engineering and Information Technology with a specialization in Neurotechnology. He graduated from the the Swiss Federal Institute of Technology in Zürich (ETHZ), Switzerland in Aug 2017. Stephan worked with APT for 3 months in Fall 2017 during an IAESTE internship. Nowadays he is working towards a PhD at ETH Zürich, Laboratory of Biosensors and Bioelectronics.
	Helene Kongshavn Arild pursued her term project at Dept. of Engineering Cybernetics during Fall 2017, on a topic related to APT and system identification. Supervised by Anders Fougner and Øyvind Stavdahl.
	Snorre Hukkelås pursued his term project at Dept. of Engineering Cybernetics during Fall 2017, on a topic related to APT and glucose monitoring. Supervised by Anders Fougner and Øyvind Stavdahl.
	Roar Tordahl Nøstbakken pursued his MSc degree at Department of Engineering Cybernetics during Spring 2017, on a topic related to APT. Roar studied the possibilities for using additional sensor modalities to identify and suppress motion artefacts in non-invasive glucose measurements.
	Sajeetha (Gita) Nagarajah pursued her master thesis in Pharmacy at Department of Laboratory Medicine, Children's and Women's Health during Fall 2016 and Spring 2017, on a topic related to APT. In an animal model she investigated how intraabdominal administration of glucagon affects circulating glucose level. Supervised by Sven M. Carlsen.
	Albert Danielsen pursued his BSc thesis at Department of Engineering Cybernetics in spring 2017, on a topic related to APT and glucose sensor calibration rig. Supervised by Patrick Bösch and Pål Gisvold.
	Anders Nilsen pursued his BSc thesis at Department of Engineering Cybernetics in spring 2017, on a topic related to APT and glucose sensor calibration rig. Supervised by Patrick Bösch and Pål Gisvold.
	Axel Hansen Grøvdal pursued his BSc thesis at Department of Engineering Cybernetics in spring 2017, on a topic related to APT and glucose sensor calibration rig. Supervised by Patrick Bösch and Pål Gisvold. He also did an internship with APT during summer and fall 2017.
	Eirik Knævelsrud received his MSc degree at Department of Engineering Cybernetics in Feb 2017, on a topic related to APT and mathematical modeling. Supervised by Anders Fougner and Sverre Hendseth.
	Nicolay Berge Erlbeck received his MSc degree at Department of Engineering Cybernetics in June 2016, on a topic related to APT, mathematical modeling and real-time system identification. Supervisors: Øyvind Stavdahl, Konstanze Kölle and Anders Fougner.
	Per Magnus Walmsness received his MSc degree at Department of Physics in June 2016. MSc thesis: Design and Analysis of Optical Fiber Probes for Glucose Sensing in the Peritoneal Cavity. Supervisor: Ursula Gibson. He is now working towards a PhD degree at NTNU, Department of Physics.
	Lars Magnus Kaasa received his MSc degree at Department of Engineering Cybernetics in July 2016, on a topic related to APT and adaptive glucose control. MS thesis: Simulert adaptiv regulering av blodsukkernivå hos diabetikere [in Norwegian]. Supervisor: Øyvind Stavdahl.
	Kaj Andreas Palm received his MSc degree at Department of Engineering Cybernetics in June 2015, on a topic related to APT and intraperitoneal glucose sensing. Supervisor: Øyvind Stavdahl.
	Håkon Øyen received his MSc degree at Department of Engineering Cybernetics in June 2015. MSc thesis: Pulsatile insulin infusion in closed-loop glucose control in diabetes mellitus type 1. Supervisors: Øyvind Stavdahl, Anders Fougner and Konstanze Kölle.
	Petter Rossvoll received his MSc degree at Department of Engineering Cybernetics in February 2015. MSc thesis: Optical dip probes for near-infrared spectroscopic glucose sensing in peritoneal fluid. Supervisors: Øyvind Stavdahl and Anders Fougner.
	Hans Erik Frøyen received his MSc degree at Department of Engineering Cybernetics in June 2014. MSc thesis: Algorithms for closed-loop glucose control in diabetes and intensive-care patients. Supervisors: Øyvind Stavdahl and Anders Fougner.

Most recent publications:

More publications:

Former employees of the APT research group:

Former students and interns of the APT research group: