Most recent publications:

Kölle, K., Biester, T., Christiansen, S. C., Fougner, A. L., and Stavdahl. Ø., Pattern Recognition Reveals Postprandial Changes in CGM Data: Non-Individualized Meal Detection in DM1, IEEE Journal of Biomedical and Health Informatics, Apr 2019. In press (Preprint).

Kölle, K., Aftab, M. F., Andersson, L. E., Fougner, A. L., and Stavdahl, Ø., Data Driven Filtering of Bowel Sounds Using Multivariate Empirical Mode Decomposition, BioMedical Engineering Online, Vol. 18, 20 Mar 2019.

Fuglerud, S. S., Milenko, K., Ellingsen, R., Aksnes, A., and Hjelme, D. R., Glucose sensing by absorption spectroscopy using lensed optical fibers, Applied Optics, Vol. 58, No. 10, pp. 2456–2462, Apr 2019.

Fougner, A. L., Åm, M. K., Bösch, P. C., Christiansen, S. C., Ellingsen, R., Hjelme, D. R., Carlsen, S. M., and Stavdahl, Ø.,Why intraperitoneal glucose sensing is sometimes surprisingly rapid and sometimes slow: A hypothesis (ePoster), ATTD 2019, Berlin, Germany, Feb 2019.

Åm, M. K., Dirnena-Fusini, I., Carlsen, S. M., Fougner, A. L., and Christiansen, S. C., Intraperitoneal and subcutaneous glucagon delivery in pigs: Effects on circulating glucagon and glucose levels (ePoster), ATTD 2019, Berlin, Germany, Feb 2019.

Dirnena-Fusini, I., Åm, M. K., Carlsen, S. M., Fougner, A. L., and Christiansen, S. C., Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels (ePoster), ATTD 2019, Berlin, Germany, Feb 2019.

2018:

Kölle, K., Towards a Safe Artificial Pancreas: Meal Detection and the Intraperitoneal Route, ISBN 978-82-326-3559-7, in: Doctoral theses at NTNU (ISSN 1503-8181), 2018:385, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Dec 2018.

Milenko, K., Fuglerud, S. S., Kjeldby, S. B., Ellingsen, R., Aksnes, A., and Hjelme, D. R., Micro-lensed optical fibers for a surface-enhanced Raman scattering sensing probe, Optics Letters, Vol. 43, No. 24, pp. 6029–6032, Dec 2018.

Jernelv, I. L., Milenko, K. B., Fuglerud, S. S., Hjelme, D. R., Ellingsen, R., Aksnes, A., A Review of Optical Methods for Continuous Glucose Monitoring, Applied spectroscopy reviews, Nov 2018.

Dirnena-Fusini, I., Åm, M. K., Fougner, A. L., Carlsen, S. M., and Christiansen, S. C., Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: A randomized controlled crossover trial, BMJ Open Diabetes Research & Care, 6(1):e000560, Nov 2018.

Kölle, K., Fougner, A. L., Lundteigen, M. A., Carlsen, S. M., Ellingsen, R., and Stavdahl, Ø., Risk Analysis for the Design of a Safe Artificial Pancreas Control System, Health and Technology, Oct 2018.

Staal, O. M., Hansen, H. M. U., Christiansen, S. C., Fougner, A. L., Carlsen, S. M., and Stavdahl, Ø., Differences Between Flash Glucose Monitor and Fingerprick Measurements, Biosensors, 8(4):93, Oct 2018.

Åm, M. K., Kölle, K., Fougner, A. L., Dirnena-Fusini, I., Bösch, P., Ellingsen, R., Hjelme, D. R., Stavdahl, Ø., Christiansen, S. C., and Carlsen, S. M., Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model, PLoS One, 13(10):e0205447, Oct 2018.

More publications:

List of APT's publications 2014–2018.

List of older publications and patents by APT members.

— A list of all scientific publications from the APT group can be found in Cristin.

The Artificial Pancreas Trondheim (APT) research group was established in 2013 at The Norwegian University of Science and Technology (NTNU) in Trondheim. APT is a cross-disciplinary group of researchers with high competence in the fields of control engineering, biomedical engineering, biosensors, applied clinical research, endocrinology, anesthesia and intensive care medicine, pharmacology, biotechnology, mathematical modelling, biochemistry and chemometrics, as well as collaboration with relevant biosensor industry.

The long-term aim of APT’s research is to develop a robust closed-loop glucose control system for patients with diabetes mellitus type 1 and 2 and for intensive-care patients, and to commercialize an artificial pancreas based on these results.

Read the Strategic statement of the Artificial Pancreas Trondheim (APT) research group. Includes vision and objectives.

News:

The APT group and Department of Engineering Cybernetics currently have a vacant PhD position within Meal Detection by Analysis of Bowel Sounds. Applications are to be submitted through JobbNorge and the deadline is 1 May 2019.
This PhD project aims to analyse recorded sounds from the upper body (mostly targeted at the intestines/bowel) in order to detect meals in patients with diabetes. The recorded sound will also be combined with continuous glucose sensor data and motion data in order to achieve larger robustness to e.g. ambient noise. The equipment is being built by SINTEF, but the PhD candidate will be involved in the design. Methods may include sensor fusion, calculation of time/frequency domain features, pattern recognition and machine learning. The APT group has access to facilities, staff and other necessary resources for acquisition of data from healthy people and diabetes patients, and the candidate will be involved in the planning and conduction of such experiments as part of a larger experienced team.

At present the group holds the following participants:

Steering group:

S. M. Carlsen Professor Sven M. Carlsen, professor in clinical research at Department of Clinical and Molecular Medicine at NTNU, Head of Unit for Clinical Research and a Consultant in endocrinology at St. Olavs Hospital. Thirty years of experience in the treatment of diabetes and has been involved in studies of glucose homeostasis in pregnancy. Prof. Carlsen is head of the APT research group.
R. Ellingsen Dr Reinold Ellingsen, Senior Advisor at Department of Electronic Systems, NTNU. He also is a co-founder and board member of GlucoSet AS, a Trondheim based private company established in 2011 on the basis of a patented fiber optic intravascular glucose sensor, previously the Invivosense technology platform. Nils Kristian Skjærvold and Petter Aadahl have used this sensor in their research.
D. R. Hjelme Professor Dag Roar Hjelme, Department of Electronic Systems, NTNU. He has more than 25 years of experience from research and development of optical fiber sensor technology. From 2000 to 2010 he was CTO in OptoMed AS and InvivoSense AS working on in vivo application of optical fiber sensor technology. He was supervisor for Sven Tierney and Nils Kristian Skjærvold during their PhDs on glucose sensor development and in vivo sensor testing. He is also a co-founder of GlucoSet AS.
Ø. Stavdahl Professor Øyvind Stavdahl, Department of Engineering Cybernetics, NTNU. He has 6 years of experience in contract research, innovation and research management from SINTEF, is the co-founder and former general manager of a startup company, co-founder and former head of the Human Motor Control (HMC) research network in Trondheim. Stavdahl has a long history of participation in mainly medical-technical transdisciplinary research.
A. L. Fougner Associate Professor Anders Fougner, Department of Engineering Cybernetics, NTNU. MSc and PhD in Engineering Cybernetics, with specialization in medical cybernetics, myoelectric prosthesis control systems. Previously employed as a postdoc in Artificial Pancreas Trondheim during 2014–2017 with focus on modelling and system identification. Fougner is also secretary/coordinator of the APT group.
S. C. Christiansen Dr Sverre Christian Christiansen, researcher at Department of Clinical and Molecular Medicine. Has worked with APT since November 2014. Consultant in Endocrinology with a PhD in epidemiology of venous thromboembolism from Leiden University Medical Center, Netherlands.
 

Participants:

A. Aksnes Professor Astrid Aksnes, Department of Electronic Systems, NTNU. She has fifteen years of experience from SINTEF and NTNU in research and development of optical sensor technology. Since year 2000 she has been member of an EU Expert panel for evaluation and review of project proposals and reports for the EU framework programmes.
T. Rølvåg Professor Terje Rølvåg, Dept. of Mechanical and Industrial Engineering, NTNU. He holds a MSc and a PhD within finite element dynamics of elastic mechanisms from NTH. His working experience includes Sintef Production Engineering, Sintef Materials Technology, Fedem Technology AS, ColiCot and TRAC, the latter in combination with an adjunct professorship at Department of Engineering Design and Materials (IPM), NTNU. Since 2003 he has been a full time professor within the Engineering Design group at IPM. Rølvåg has 30 years of experience in Product Development with a focus on Computer Aided Engineering. His role is to develop and optimize AP concepts with respect to design and functionality for experimental and commercial use.
K. Milenko Dr Karolina Milenko, postdoctoral research fellow at Department of Electronic Systems, NTNU. MSc and PhD in Physics, with specialization in optical fiber sensing technologies. Employed as a postdoc in Artificial Pancreas Trondheim since June 2016, she focuses on design and development of novel sensing devices for intraperitoneal glucose levels, based on optical spectroscopy methods.​
T. S. Sunilkumar Dr Telagam Setti Sunilkumar is an ERCIM postdoctoral research fellow at the Department Engineering Cybernetics. He received his Ph.D. in Electrical Engineering from the Indian Institute of Technology Indore. His research areas are digital signal processing and machine learning. He is employed as a postdoc in Artificial Pancreas Trondheim since February 2019. His focus is on meal detection based on sound recordings.
C. L. Zazueta Dr Claudia Lopez Zazueta is an ERCIM postdoctoral research fellow at the Department Engineering Cybernetics. MSc in Physics and Mathematics (University of Granada, Spain), with specialization in Mathematical Methods and Models in Science and Engineering, and MSc in Mathematical Sciences (UNAM, Mexico). PhD in Control, Signal and Image Processing (Inria, France). Employed as a postdoc in Artificial Pancreas Trondheim since February 2019, she focuses on mathematical modeling and system identification.
M. K. Aam Marte Kierulf Åm received her Cand.med.vet. from the Norwegian School of Veterinary Science in 2006. She started working as a PhD candidate for APT in January 2016. She will primarily focus on glucose sensing in the intraperitoneal cavity and is the main responsible for animal trials.
I. Dirnena-Fusini Ilze Dirnena-Fusini received her MSc degree in Natural Science at University of Latvia in 2012. She completed her studies at Paul Stradins Health and Social Care College, where she received education in internal medicine and attained the diploma of Biomedical Laboratory Assistant. She started working as a PhD candidate for APT in February 2016. She will primarily focus on insulin absorption in the intraperitoneal cavity. Funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU). Currently on maternity leave (June 2017 - January 2018).
I. L. Jernelv Ine Larsen Jernelv received her MSc degree in Nanotechnology from NTNU in 2015 and started working for APT as a PhD candidate in May 2016. She will focus on investigating optical spectroscopy of peritoneal fluid for glucose sensing, both in vitro and in vivo.
S. S. Fuglerud Silje Skeide Fuglerud received her MSc degree in Applied Physics from NTNU in 2016, with a specialization in biophysical applications of optics and microfluidics. She wrote her MSc thesis on “Evanescent light field trapping and transport of micro- and nanocrystals of biological macromolecules on a waveguide for serial crystallography” at Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany. Silje is a PhD candidate with APT since 2017 and works with methods for optical spectroscopy and sensor fusion. Funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU).
H. Khoshamadi Hasti Khoshamadi works as a PhD candidate in APT since March 2019. Received her MSc degree in Electrical Engineering (Control) from K. N. Toosi University of Technology, Tehran, Iran, November 2018. Her focus is on mathematical modeling and system identification. Supervised by Anders Fougner.
P. Bösch Patrick Bösch, BSc in Systems Engineering with a specialization in Biomedical Engineering. He graduated from the Zürich University of Applied Science (ZHAW) in Winterthur, Switzerland in 2015. Prior to that he did an apprenticeship as an electrician in Switzerland. Patrick worked with APT for 8 weeks in summer 2015 during an IAESTE internship. Since February 2016 he works for APT as a Staff engineer in the function of a Development Engineer. He is primarily focused on design and prototyping of novel instrumentation based on optical spectroscopy and other relevant sensing modalities for the measurement of glucose in peritoneal fluid, as well as the associated insulin infusion mechanism and related components and systems.
W. Azam

Waleed Azam pursues his MSc at Dept. of Electronic Systems and works for APT in a 15% position during the Spring 2019. His work consists of programming tasks, which focus on interfacing experimental hardware with advanced control software.
 

Former employees of APT:

Listed here.
 

Associated:

P. Aadahl Professor Petter Aadahl, professor in anestesiology at Department of Circulation and Medical Imaging, NTNU. Consultant and former Research Director at St. Olavs Hospital. Long standing interest in glucose monitoring in intensive care units (ICU). Supervisor for Nils Kristian Skjærvold during his PhD on a new glucose sensor.
N. K. Skjærvold Dr Nils Kristian Skjærvold, MD, PhD, Department of Anesthesia and Intensive Care Medicine, St. Olavs Hospital, and Postdoctoral research fellow at Dept. of Circulation and Medical Imaging at NTNU. Skjærvold has clinical experience in all aspects of anesthesia and intensive care medicine as well as in experimental studies in large animals. In November 2012 he defended his PhD thesis entitled “Automated blood glucose control – development and testing of an artificial endocrine pancreas using a novel intravascular glucose monitor and a new approach to insulin pharmacology”. Since January 2015 he is a postdoctoral research fellow on a topic related to APT (Personalized care of critically-ill patients with time-series analysis of oscillating physiology). Currently funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU).
S. W. Omholt Professor Stig William Omholt, Faculty of Medicine at NTNU, has a long experience in mathematical modeling, systems biology and experimental biology, and in leading multidisciplinary projects involving the concerted operation of experimental and theoretical elements.
H. Aa. Martens Adjunct Professor Harald Aa. Martens, holds a siv.ing. (M.Sc) in biochemistry and dr.techn. in chemometrics. He has 40 years of experience in multivariate datamodelling, in particular for calibration of multichannel instruments to eliminate unexpected interference problems in e.g. biospectroscopy, for interdisciplinary, statistically valid data analysis linking “hard” and “soft” data, and for metamodelling to facilitate high-dimensional nonlinear dynamic models, in particular of complex human and animal physiology. He has published more than 200 papers and several books on these topics. He is currently affiliated with the Department of Engineering Cybernetics at NTNU.
O. Spigset Professor Olav Spigset, M.D., PhD is Senior Consultant, Department of Clinical Pharmacology, St. Olavs Hospital and Professor of Clinical Pharmacology, NTNU. He has extensive research experience in clinical pharmacology with focus on pharmacokinetics, pharmacogenetics and drug safety, and has published more than 250 scientific articles. Among other tasks, he is Editor of a Norwegian textbook in pharmacology, has created a national internet-based drug interaction database (www.interaksjoner.no) and is head of the Editorial board of the Norwegian medicines handbook (Norsk legemiddelhåndbok).
 

Industrial partners:

Logo for Prediktor Medical Artificial Pancreas Trondheim has a collaboration with Prediktor Medical AS, a Norwegian company based in Fredrikstad.
O. M. Staal Odd Martin Staal is an industrial PhD candidate with Prediktor Medical and APT/NTNU since 2015. Defending his PhD degree publicly at 10 May 2019. MSc (2006) in Engineering Cybernetics with 2 years experience from the Norwegian Defence Research Establishment and 6.5 years experience from medical device development in Axis-Shield PoC. Supervised by Øyvind Stavdahl, Steinar Sælid, Anders L. Fougner and Sven M. Carlsen.
 

Students, Spring 2019:

E. Søiland

Elise Søiland pursues her MSc thesis at Dept. of Engineering Cybernetics during Spring 2019, on a topic related to analysis of bowel sounds. Supervised by Anders Fougner.
P. M. Stige

Peter Martinius Stige pursues his MSc thesis at Dept. of Engineering Cybernetics during Spring 2019, on a topic related to Prediktor Medical AS. Supervised by Anders Fougner and Steinar Sælid.
L. S. Sæle

Ludvig S. Sæle pursues a term project at Dept. of Engineering Cybernetics during Spring 2019, on a topic related to analysis of bowel sounds. Supervised by Anders Fougner.
K. Strøm

Karina Strøm pursues her MSc thesis at Dept. of Electronic Systems during Spring 2019, on a topic related to optical glucose sensors. Supervised by Astrid Aksnes and Ine Larsen Jernelv.
A. G. Thorbjørnsrud

Andreas Grue Thorbjørnsrud pursues his MSc in Pharmacy at Department of Clinical and Molecular Medicine during Fall 2018 and Spring 2019, on a topic related to APT. He will perform a literature review on ways to enhance the absorption of drugs with special emphasis on insulin and glucagon. Supervised by Sven M. Carlsen.
S. N. Finne

Solveig Nyland Finne pursues her MSc in Pharmacy at Department of Clinical and Molecular Medicine during Fall 2018 and Spring 2019, on a topic related to APT. She will study ways of enhancing the absorption of subcutaneous delivered insulin. Supervised by Sven M. Carlsen.
 

Former employees and students of APT:

Listed here.

 


Contact: Sven M. Carlsen
Address: Dept. of Clinical and Molecular Medicine, NTNU, Olav Kyrres gate 10, NO-7491 Trondheim, Norway
E-mail: sven.carlsen@ntnu.no
Phone: +47 72571109
Mobile phone: +47 91769528

 

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