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Most recent publications:

Fougner, A. L., Kölle, K., Skjærvold, N. K., Elvemo, N. A., Hjelme, D. R., Ellingsen, R., Carlsen, S. M., and Stavdahl, Ø., Intraperitoneal Glucose Sensing is Sometimes Surprisingly Rapid, Modeling, Identification and Control (MIC), Vol. 37, No. 2, pp. 121-131, August 2016.

Stavdahl, Ø., Fougner, A. L., Kölle, K., Christiansen, S. C., Ellingsen, R., and Carlsen, S. M., The Artificial Pancreas: A Dynamic Challenge (paper), IFAC DYCOPS-CAB 2016, Trondheim, Norway, June 2016.

Carlsen, S. M., Fougner, A. L., Karstang, T. V., Staal, O. M., and Christiansen, S. C., Continuous Non-Invasive Glucose Monitoring by Sensor Fusion of Near Infrared Light and Bioimpedance Measurements: Results of a Proof of Concept Study (ePoster), ATTD 2016, Milano, Italy, February 2016.

Kölle, K., Fougner, A. L., Carlsen, S. M., Ellingsen, R., and Stavdahl, Ø., Failure Analysis of an Artificial Pancreas — Double Subcutaneous vs. Double Intraperitoneal Approach (ePoster), ATTD 2016, Milano, Italy, February 2016.

Fougner, A., Kölle, K., Skjærvold, N. K., Elvemo, N. A., Ellingsen, R., Carlsen, S. M., and Stavdahl, Ø., Intraperitoneal Glucose Sensing — Rapid and Accurate (ePoster), ATTD 2015, Paris, France, February 2015.

Fougner, A., Kölle, K., Frøyen, H. E. F., Ellingsen, R., Carlsen, S. M., and Stavdahl, Ø., In-silico Comparison of Intravenous, Intraperitoneal, Subcutaneous and Combined Approaches for Closed-Loop Glucose Control (ePoster), ATTD 2015, Paris, France, February 2015.

Kölle, K., Fougner, A., Frøyen, H. E. F., and Stavdahl, Ø., Modelling Insulin and Glucose Dynamics in Diabetes Mellitus Type 1: Intravenous, Subcutaneous and Intraperitoneal Approach, VPH Conference 2014, NTNU, Trondheim, Norway, September 2014.

Skjærvold, N. K., Fougner, A., and Elvemo, N. L., Intelligent Predictive Artificial Pancreas by Biomimicry of the Native Beta Cells — Concept, Prototype and the Future, VPH Conference 2014, NTNU, Trondheim, Norway, September 2014.

Other publications:

— A list of publications from the APT group can be found in Cristin.

— A list of other publications and patents by APT members can be found here.






The Artificial Pancreas Trondheim (APT) research group was established in 2013 at The Norwegian University of Science and Technology (NTNU) in Trondheim. APT is a cross-disciplinary group of researchers with high competence in the fields of control engineering, biomedical engineering, biosensors, applied clinical research, endocrinology, anesthesia and intensive care medicine, pharmacology, biotechnology, mathematical modelling, biochemistry and chemometrics, as well as collaboration with relevant biosensor industry.

The long-term aim of APT’s research is to develop a robust closed-loop glucose control system for patients with diabetes mellitus type 1 and 2 and for intensive-care patients, and to commercialize an artificial pancreas based on these results.

Read the Strategic statement of the Artificial Pancreas Trondheim (APT) research group.

News:

  • 6-8 June: APT had a presentation at the Artificial Pancreas session of the IFAC DYCOPS-CAB 2016 (Symposium on Dynamics and Control of Process Systems, including Biosystems), which was held in Trondheim, Norway. Our paper has been published here: The Artificial Pancreas: A Dynamic Challenge.
  • 4 May: APT's project was featured in forskning.no (in Norwegian).
  • 26 April: Sven M. Carlsen gave a short presentation of the “Double Intraperitoneal Artificial Pancreas” at a Tekna Biotek seminar at NTNU.
  • 19-20 April: Members of the APT Research Group participated on the opening conference in Trondheim for the Centre for Digital Life Norway. Sven M. Carlsen gave a short presentation of the “Double Intraperitoneal Artificial Pancreas”. This research project is one of the first six research projects funded by the Norwegian Research Council as part of the Centre for Digital Life Norway.
  • 15 April: Sven M. Carlsen gave a presentation at the weekly scientific assembly at St. Olav University Hospital in Trondheim, entitled "Artificial Pancreas - Fact or Fiction?"
  • 9 March 2016: Anders L. Fougner presented the APT research group and its Double Intraperitoneal Artificial Pancreas concept at the 3 days winter meeting of The Norwegian Society of Endocrinology in Tromsø, Norway. The same day Sven M. Carlsen gave a presentation on continuous glucose measurements with focus on the limitations of subcutaneous measurements for the use in an artificial pancreas.
  • 3-6 Feb 2016: six members of the APT research group attended the ATTD conference in Milan, Italy and presented two posters (see links in the left menu). Also attending the conference were two representatives from the Norwegian company Prediktor Medical AS which collaborates with the APT research group.
  • 30 Nov - 1 Dec 2015: We arranged the 2nd APT workshop here in Trondheim. About 20 participants shared their knowledge. Photo.
  • 30 September 2015: APT was granted 5 years of funding from the Norwegian Research Council’s strategic biotechnology initative National Centre for Digital Life announced here (in Norwegian).

At present the group holds the following participants:

Steering group:

S. M. Carlsen Professor Sven M. Carlsen, professor in clinical research at Department of Cancer Research and Molecular Medicine at NTNU, Head of Unit for Clinical Research and a Consultant in endocrinology at St. Olavs Hospital. Thirty years of experience in the treatment of diabetes and has been involved in studies of glucose homeostasis in pregnancy. Prof. Carlsen is head of the APT research group.
Dr Reinold Ellingsen, Senior Advisor at Department of Electronics and Telecommunications, NTNU. He also is a co-founder and board member of GlucoSet AS, a Trondheim based private company established in 2011 on the basis of a patented fiber optic intravascular glucose sensor, previously the Invivosense technology platform. Nils Kristian Skjærvold and Petter Aadahl have used this sensor in their research.
Associate Professor Øyvind Stavdahl, Department of Engineering Cybernetics, NTNU. He has 6 years of experience in contract research, innovation and research management from SINTEF, is the co-founder and former general manager of a startup company, co-founder and former head of the Human Motor Control (HMC) research network in Trondheim. Stavdahl has a long history of participation in mainly medical-technical transdisciplinary research.
Dr Anders Fougner, postdoctoral research fellow at Department of Engineering Cybernetics, NTNU. MSc and PhD in Engineering Cybernetics, with specialization in medical cybernetics, myoelectric prosthesis control systems. He has diabetes mellitus type 1 himself. Employed as a postdoc in Artificial Pancreas Trondheim since January 2014. Dr Fougner is also secretary for the APT group.
 

Other participants:

Professor Astrid Aksnes, Department of Electronics and Telecommunications, NTNU. She has fifteen years of experience from SINTEF and NTNU in research and development of optical sensor technology. Since year 2000 she has been member of an EU Expert panel for evaluation and review of project proposals and reports for the EU framework programmes.
Professor Dag Roar Hjelme, Dept. of Electronics and Telecommunications and Dept. of Electrical Engineering and Renewable Energy, NTNU. He has more than 25 years of experience from research and development of optical fiber sensor technology. From 2000 to 2010 he was CTO in OptoMed AS and InvivoSense AS working on in vivo application of optical fiber sensor technology. He was supervisor for Sven Tierney and Nils Kristian Skjærvold during their PhDs on glucose sensor development and in vivo sensor testing. He is also a co-founder of GlucoSet AS.
Professor Petter Aadahl, professor in anestesiology at Department of Circulation and Medical Imaging, NTNU. Research Director and a Consultant at St. Olavs Hospital. Long standing interest in glucose monitoring in intensive care units (ICU). Supervisor for Nils Kristian Skjærvold during his PhD on a new glucose sensor.
Professor Stig William Omholt, Faculty of Medicine at NTNU, has a long experience in mathematical modeling, systems biology and experimental biology, and in leading multidisciplinary projects involving the concerted operation of experimental and theoretical elements.
Adjunct Professor Harald A. Martens, holds a siv.ing. (M.Sc) in biochemistry and dr.techn. in chemometrics. He has 40 years of experience in multivariate datamodelling, in particular for calibration of multichannel instruments to eliminate unexpected interference problems in e.g. biospectroscopy, for interdisciplinary, statistically valid data analysis linking “hard” and “soft” data, and for metamodelling to facilitate high-dimensional nonlinear dynamic models, in particular of complex human and animal physiology. He has published more than 200 papers and several books on these topics. He is currently affiliated with the Department of Engineering Cybernetics at NTNU.
Professor Olav Spigset, M.D., PhD is Senior Consultant, Department of Clinical Pharmacology, St. Olav Hospital and Professor of Clinical Pharmacology, NTNU. He has extensive research experience in clinical pharmacology with focus on pharmacokinetics, pharmacogenetics and drug safety, and has published more than 250 scientific articles. Among other tasks, he is Editor of a Norwegian textbook in pharmacology, has created a national internet-based drug interaction database (www.interaksjoner.no) and is head of the Editorial board of the Norwegian medicines handbook (Norsk legemiddelhåndbok).
Dr Nils Kristian Skjærvold, MD, PhD, Department of Anesthesia and Intensive Care Medicine, St. Olavs Hospital, and Postdoctoral research fellow at Dept. of Circulation and Medical Imaging at NTNU. Skjærvold has clinical experience in all aspects of anesthesia and intensive care medicine as well as in experimental studies in large animals. In November 2012 he defended his PhD thesis entitled “Automated blood glucose control – development and testing of an artificial endocrine pancreas using a novel intravascular glucose monitor and a new approach to insulin pharmacology”. Since January 2015 he is a postdoctoral research fellow on a topic related to APT (Personalized care of critically-ill patients with time-series analysis of oscillating physiology).
Dr Sverre Christian Christiansen, researcher at Department of Cancer Research and Molecular Medicine. Has worked with APT since November 2014. Consultant in Endocrinology with a PhD in epidemiology of venous thromboembolism from Leiden University Medical Center, Netherlands.
Konstanze Kölle received her MSc degree in Chemical Engineering at RWTH Aachen University and has worked for APT as a PhD candidate since 2 May 2014. Her research topic is "Development of control algorithms and safety mechanisms for closed-loop glucose control in patients with diabetes mellitus type 1 and 2 and in intensive-care patients."
Marte Kierulf Åm received her Cand.med.vet. from the Norwegian School of Veterinary Science in 2006. She started working as a PhD candidate for APT in January 2016. Her work will primarily focus on glucose sensing in the intraperitoneal cavity.
Ilze Dirnena-Fusini received her MSc degree in Natural Science at University of Latvia in 2012. She completed her studies at Paul Stradins Health and Social Care College, where she received education in internal medicine and attained the diploma of Biomedical Laboratory Assistant. She started working as a PhD candidate for APT in February 2016. Her work focuses on insulin absorption in the intraperitoneal cavity.
 
Patrick Bösch, BSc in Systems Engineering with a specialization in Biomedical Engineering. He graduated from the Zürich University of Applied Science (ZHAW) in Winterthur, Switzerland in 2015. Prior to that he did an apprenticeship as an electrician in Switzerland. Since February 2016 he works for APT as a Staff engineer in the function of a Development Engineer. His work is primarily focused on design and prototyping of novel instrumentation based on optical spectroscopy and other relevant sensing modalities for the measurement of glucose in peritoneal fluid, as well as the associated insulin infusion mechanism and related components and systems.
 
Ine Larsen Jernelv received her MSc degree in Nanotechnology from NTNU in 2015 and started working for APT as a PhD candidate in May 2016. Her work will focus on investigating optical spectroscopy of peritoneal fluid for glucose sensing, both in vitro and in vivo.
 
Dr Karolina Milenko, postdoctoral research fellow at Department of Electronics and Telecommunications, NTNU. MSc and PhD in Physics, with specialization in optical fiber sensing technologies. Employed as a postdoc in Artificial Pancreas Trondheim since June 2016, her work focuses on design and development of novel sensing devices for intraperitoneal glucose levels, based on optical spectroscopy methods.​
 



Industrial partners:

Artificial Pancreas Trondheim has a collaboration with Prediktor Medical AS, a Norwegian company based in Fredrikstad.
 
 

Master students, Fall 2016:



Sajeetha (Gita) Nagarajah pursues her MSc in Pharmacy at Department of Laboratory Medicine, Children's and Women's Health during Fall 2016 and Spring 2017, on a topic related to APT. In an animal model she will investigate how intraabdominal administration of glucagon affects the glucose level.




Roar Nøstebakken pursues his term project at Department of Engineering Cybernetics during Fall 2016, on a topic related to APT. Roar will study the possibilities for using additional sensor modalities to identify and suppress motion artefacts in non-invasive glucose measurements.




Edel Lovise Gjelstad pursues her term project at Department of Engineering Cybernetics during Fall 2016, on a topic related to APT and meal detection/estimation. Supervised by Konstanze Kölle and Øyvind Stavdahl.


 
 

Former master students in APT:

Listed here.
 
 

Contact: Sven M. Carlsen
Address: Dept. of Cancer Research and Molecular Medicine, NTNU, Olav Kyrres gate 10, NO-7491 Trondheim, Norway
E-mail: sven.carlsenntnu.no
Phone: +47 72571109
Mobile phone: +47 91769528