Most recent publications:

Christiansen, S. C., Fougner, A. L, Stavdahl, Ø., Kölle, K., Ellingsen, R., and Carlsen, S. M., A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach, Diabetes Therapy, Vol. 8, pp. 1–18, May 2017.

Christiansen, S. C., and Carlsen, S. M., Kunstig pankreas – drøm eller virkelighet?, Indremedisineren, Vol. 7, No. 1, pp. 30–33, Apr 2017.

Kölle, K., Fougner, A. L., and Stavdahl, Ø., On the Sensitivity of Continuous Glucose Monitoring to Insulin Infusion Faults (ePoster), ATTD 2017, Paris, France, Feb 2017.

Åm, M. K., Fougner, A. L., Bösch, P., Dirnena-Fusini, I., Kölle, K., Stavdahl, Ø., Ellingsen, R., Hjelme, D. R., Christiansen, S. C., and Carlsen, S. M., Intraperitoneal glucose measuring using amperometric glucose sensors and intraperitoneal fluid samples in an animal model (ePoster), ATTD 2017, Paris, France, Feb 2017.

Staal, O. M., Sælid, S., Karstang, T. V., and Stavdahl, Ø., Kalman Smoothing of Glucose Data Applied to Partial Least Squares Modeling of Non-Invasive Near-Infrared Measurements (ePoster), ATTD 2017, Paris, France, Feb 2017.

Bösch, P., Åm, M. K., Stavdahl, Ø., Fougner, A. L., Carlsen, S. M., Ellingsen, R., and Hjelme, D. R., Set-up and procedure for intraperitoneal glucose monitoring in anaesthetised animals (ePoster), ATTD 2017, Paris, France, Feb 2017.

Dirnena-Fusini, I., Åm, M. K., Christiansen, S. C., Fougner, A. L., Carlsen, S. M., Physiologic effects of intraperitoneal vs. subcutaneous insulin delivery in patients with DM1: A systematic review (ePoster), ATTD 2017, Paris, France, Feb 2017.

Fougner, A. L., Kölle, K., Skjærvold, N. K., Elvemo, N. A., Hjelme, D. R., Ellingsen, R., Carlsen, S. M., and Stavdahl, Ø., Intraperitoneal Glucose Sensing is Sometimes Surprisingly Rapid, Modeling, Identification and Control (MIC), Vol. 37, No. 2, pp. 121–131, Aug 2016.

Stavdahl, Ø., Fougner, A. L., Kölle, K., Christiansen, S. C., Ellingsen, R., and Carlsen, S. M., The Artificial Pancreas: A Dynamic Challenge (paper), IFAC DYCOPS-CAB 2016, Trondheim, Norway, Jun 2016.

More publications:

— A list of all scientific publications from the APT group can be found in Cristin.

— A list of other publications and patents by APT members can be found here.

The Artificial Pancreas Trondheim (APT) research group was established in 2013 at The Norwegian University of Science and Technology (NTNU) in Trondheim. APT is a cross-disciplinary group of researchers with high competence in the fields of control engineering, biomedical engineering, biosensors, applied clinical research, endocrinology, anesthesia and intensive care medicine, pharmacology, biotechnology, mathematical modelling, biochemistry and chemometrics, as well as collaboration with relevant biosensor industry.

The long-term aim of APT’s research is to develop a robust closed-loop glucose control system for patients with diabetes mellitus type 1 and 2 and for intensive-care patients, and to commercialize an artificial pancreas based on these results.

Read the Strategic statement of the Artificial Pancreas Trondheim (APT) research group. Includes vision and objectives.

News:

  • 23-25 August 2017: Professor Francis J Doyle III will visit us to hold a "Volterra Lecture" for Centre for Digital Life (DLN) and Artificial Pancreas Trondheim. See the announcement on DLN's web pages.
  • 11-16 June 2017: APT members participate in the 9th International Conference on Advanced Vibrational Spectroscopy in Victoria, Canada. Karolina Milenko presents "Optical Fiber Probe based on Raman Spectroscopy for Continuous Glucose Monitoring" and Ine Jernelv presents a poster titled "Optimising Multivariate Models for Glucose Measurements in an ATR-FTIR Spectrometer".
  • 2 June 2017: Three BSc students (Albert Danielsen, Axel Hansen Grøvdal and Anders Nilsen) presented their project Glucose sensor test rig at today's APT meeting.
  • 13 May 2017: Sverre Chr. Christiansen et al. published the paper A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach in Diabetes Therapy.
  • 1 May 2017: Several APT members were interviewed in an article in Teknisk Ukeblad (a weekly Norwegian popular science magazine).
  • 25 April 2017: Sverre Chr. Christiansen and Sven M. Carlsen published an article in Indremedisineren today [in Norwegian].
  • 25 April 2017: Digital Life Norway has launched their new web pages. Among other things, it contains a page describing our project Double Intraperitoneal Artificial Pancreas.
  • 19-21 March 2017: Most of the APT members participated at the Digital Life 2017 conference in Oslo, the annual conference by Centre for Digital Life Norway. Sven M. Carlsen gave a talk on "Double Intraperitoneal Artificial Pancrteas - A really interdisciplinary research project" and Konstanze Kölle presented "On the Sensitivity of Continuous Glucose Monitoring to Insulin Infusion Faults." Several posters were also presented by APT members.
  • 15-18 Feb 2017: Ten members of the APT research group attended the ATTD conference in Paris, France and presented five posters (see links in the left menu). Also attending the conference were three representatives from the Norwegian company Prediktor Medical AS which collaborates with the APT research group.
  • 19 December 2016: APT arranged a Christmas seminar/workshop here in Trondheim. 15 participants shared their knowledge.
  • 4 November 2016: APT was granted funding for another PhD position from Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU). The position will be announced shortly.
  • 14 October 2016: Sven M. Carlsen gave a 40 minutes long presentation entitled “Artificial Pancreas: - Fact or Fiction?” in Oslo at the annual autumn meeting for the Norwegian Society of Internal Medicine.
  • 6-8 June 2016: APT had a presentation at the Artificial Pancreas session of the IFAC DYCOPS-CAB 2016 (Symposium on Dynamics and Control of Process Systems, including Biosystems), which was held in Trondheim, Norway. Our paper has been published here: The Artificial Pancreas: A Dynamic Challenge.

At present the group holds the following participants:

Steering group:

S. M. Carlsen Professor Sven M. Carlsen, professor in clinical research at Department of Cancer Research and Molecular Medicine at NTNU, Head of Unit for Clinical Research and a Consultant in endocrinology at St. Olavs Hospital. Thirty years of experience in the treatment of diabetes and has been involved in studies of glucose homeostasis in pregnancy. Prof. Carlsen is head of the APT research group.
R. Ellingsen Dr Reinold Ellingsen, Senior Advisor at Department of Electronic Systems, NTNU. He also is a co-founder and board member of GlucoSet AS, a Trondheim based private company established in 2011 on the basis of a patented fiber optic intravascular glucose sensor, previously the Invivosense technology platform. Nils Kristian Skjærvold and Petter Aadahl have used this sensor in their research.
Ø. Stavdahl Associate Professor Øyvind Stavdahl, Department of Engineering Cybernetics, NTNU. He has 6 years of experience in contract research, innovation and research management from SINTEF, is the co-founder and former general manager of a startup company, co-founder and former head of the Human Motor Control (HMC) research network in Trondheim. Stavdahl has a long history of participation in mainly medical-technical transdisciplinary research.
A. L. Fougner Dr Anders Fougner, postdoctoral research fellow at Department of Engineering Cybernetics, NTNU. MSc and PhD in Engineering Cybernetics, with specialization in medical cybernetics, myoelectric prosthesis control systems. Employed as a postdoc in Artificial Pancreas Trondheim since January 2014 with focus on modelling and system identification. Dr Fougner is also secretary for the APT group. Currently funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU).
 

Participants:

A. Aksnes Professor Astrid Aksnes, Department of Electronic Systems, NTNU. She has fifteen years of experience from SINTEF and NTNU in research and development of optical sensor technology. Since year 2000 she has been member of an EU Expert panel for evaluation and review of project proposals and reports for the EU framework programmes.
D. R. Hjelme Professor Dag Roar Hjelme, Department of Electronic Systems, NTNU. He has more than 25 years of experience from research and development of optical fiber sensor technology. From 2000 to 2010 he was CTO in OptoMed AS and InvivoSense AS working on in vivo application of optical fiber sensor technology. He was supervisor for Sven Tierney and Nils Kristian Skjærvold during their PhDs on glucose sensor development and in vivo sensor testing. He is also a co-founder of GlucoSet AS.
T. Rølvåg Professor Terje Rølvåg, Dept. of Mechanical and Industrial Engineering, NTNU. He holds a MSc and a PhD within finite element dynamics of elastic mechanisms from NTH. His working experience includes Sintef Production Engineering, Sintef Materials Technology, Fedem Technology AS, ColiCot and TRAC, the latter in combination with an adjunct professorship at Department of Engineering Design and Materials (IPM), NTNU. Since 2003 he has been a full time professor within the Engineering Design group at IPM. Rølvåg has 30 years of experience in Product Development with a focus on Computer Aided Engineering. His role is to develop and optimize AP concepts with respect to design and functionality for experimental and commercial use.
S. C. Christiansen Dr Sverre Christian Christiansen, researcher at Department of Cancer Research and Molecular Medicine. Has worked with APT since November 2014. Consultant in Endocrinology with a PhD in epidemiology of venous thromboembolism from Leiden University Medical Center, Netherlands.
K. Milenko Dr Karolina Milenko, postdoctoral research fellow at Department of Electronic Systems, NTNU. MSc and PhD in Physics, with specialization in optical fiber sensing technologies. Employed as a postdoc in Artificial Pancreas Trondheim since June 2016, she focuses on design and development of novel sensing devices for intraperitoneal glucose levels, based on optical spectroscopy methods.​
N. K. Skjærvold Dr Nils Kristian Skjærvold, MD, PhD, Department of Anesthesia and Intensive Care Medicine, St. Olavs Hospital, and Postdoctoral research fellow at Dept. of Circulation and Medical Imaging at NTNU. Skjærvold has clinical experience in all aspects of anesthesia and intensive care medicine as well as in experimental studies in large animals. In November 2012 he defended his PhD thesis entitled “Automated blood glucose control – development and testing of an artificial endocrine pancreas using a novel intravascular glucose monitor and a new approach to insulin pharmacology”. Since January 2015 he is a postdoctoral research fellow on a topic related to APT (Personalized care of critically-ill patients with time-series analysis of oscillating physiology). Currently funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU).
K. Kölle Konstanze Kölle received her MSc degree in Chemical Engineering at RWTH Aachen University and has worked for APT as a PhD candidate since 2 May 2014. Her research topic is "Development of control algorithms and safety mechanisms for closed-loop glucose control in patients with diabetes mellitus type 1 and 2 and in intensive-care patients." Currently funded by Samarbeidsorganet (the Liaison Committee between the Central Norway Regional Health Authority and NTNU).
M. K. Aam Marte Kierulf Åm received her Cand.med.vet. from the Norwegian School of Veterinary Science in 2006. She started working as a PhD candidate for APT in January 2016. She will primarily focus on glucose sensing in the intraperitoneal cavity.
I. Dirnena-Fusini Ilze Dirnena-Fusini received her MSc degree in Natural Science at University of Latvia in 2012. She completed her studies at Paul Stradins Health and Social Care College, where she received education in internal medicine and attained the diploma of Biomedical Laboratory Assistant. She started working as a PhD candidate for APT in February 2016. She will primarily focus on insulin absorption in the intraperitoneal cavity.
I. L. Jernelv Ine Larsen Jernelv received her MSc degree in Nanotechnology from NTNU in 2015 and started working for APT as a PhD candidate in May 2016. She will focus on investigating optical spectroscopy of peritoneal fluid for glucose sensing, both in vitro and in vivo.
P. Bösch Patrick Bösch, BSc in Systems Engineering with a specialization in Biomedical Engineering. He graduated from the Zürich University of Applied Science (ZHAW) in Winterthur, Switzerland in 2015. Prior to that he did an apprenticeship as an electrician in Switzerland. Patrick worked with APT for 8 weeks in summer 2015 during an IAESTE internship. Since February 2016 he works for APT as a Staff engineer in the function of a Development Engineer. He is primarily focused on design and prototyping of novel instrumentation based on optical spectroscopy and other relevant sensing modalities for the measurement of glucose in peritoneal fluid, as well as the associated insulin infusion mechanism and related components and systems.
S. S. Fuglerud Silje Skeide Fuglerud received her MSc degree in Applied Physics from NTNU in 2016, with a specialization in biophysical applications of optics and microfluidics. She wrote her MSc thesis on “Evanescent light field trapping and transport of micro- and nanocrystals of biological macromolecules on a waveguide for serial crystallography” at Deutsches Elektronen-Synchrotron (DESY) in Hamburg, Germany. Silje will work with methods for optical spectroscopy and sensor fusion.
 

Associated:

P. Aadahl Professor Petter Aadahl, professor in anestesiology at Department of Circulation and Medical Imaging, NTNU. Research Director and a Consultant at St. Olavs Hospital. Long standing interest in glucose monitoring in intensive care units (ICU). Supervisor for Nils Kristian Skjærvold during his PhD on a new glucose sensor.
S. W. Omholt Professor Stig William Omholt, Faculty of Medicine at NTNU, has a long experience in mathematical modeling, systems biology and experimental biology, and in leading multidisciplinary projects involving the concerted operation of experimental and theoretical elements.
H. Aa. Martens Adjunct Professor Harald Aa. Martens, holds a siv.ing. (M.Sc) in biochemistry and dr.techn. in chemometrics. He has 40 years of experience in multivariate datamodelling, in particular for calibration of multichannel instruments to eliminate unexpected interference problems in e.g. biospectroscopy, for interdisciplinary, statistically valid data analysis linking “hard” and “soft” data, and for metamodelling to facilitate high-dimensional nonlinear dynamic models, in particular of complex human and animal physiology. He has published more than 200 papers and several books on these topics. He is currently affiliated with the Department of Engineering Cybernetics at NTNU.
O. Spigset Professor Olav Spigset, M.D., PhD is Senior Consultant, Department of Clinical Pharmacology, St. Olavs Hospital and Professor of Clinical Pharmacology, NTNU. He has extensive research experience in clinical pharmacology with focus on pharmacokinetics, pharmacogenetics and drug safety, and has published more than 250 scientific articles. Among other tasks, he is Editor of a Norwegian textbook in pharmacology, has created a national internet-based drug interaction database (www.interaksjoner.no) and is head of the Editorial board of the Norwegian medicines handbook (Norsk legemiddelhåndbok).
 

Industrial partners:

Logo for Prediktor Medical Artificial Pancreas Trondheim has a collaboration with Prediktor Medical AS, a Norwegian company based in Fredrikstad.
 

Students, Spring 2017:

S. Nagarajah

Sajeetha (Gita) Nagarajah pursued her MSc in Pharmacy at Department of Laboratory Medicine, Children's and Women's Health during Fall 2016 and Spring 2017, on a topic related to APT. In an animal model she investigated how intraabdominal administration of glucagon affects circulating glucose level. Supervised by Sven M. Carlsen.
R. T. Nøstbakken

Roar Tordahl Nøstbakken pursues his MSc degree at Department of Engineering Cybernetics during Spring 2017, on a topic related to APT. Roar will study the possibilities for using additional sensor modalities to identify and suppress motion artefacts in non-invasive glucose measurements.
K. A. Unstad

Karl Arthur Unstad pursued his term project at Department of Engineering Cybernetics during Spring 2017, on a topic related to APT and fault detection. Supervised by Konstanze Kölle, Anders Fougner and Øyvind Stavdahl.
A. Danielsen

Albert Danielsen pursued his BSc degree at Department of Engineering Cybernetics during spring 2017, on a topic related to APT and glucose sensor calibration rig. Supervised by Patrick Bösch and Pål Gisvold.
A. Nilsen

Anders Nilsen pursued his BSc degree at Department of Engineering Cybernetics during spring 2017, on a topic related to APT and glucose sensor calibration rig. Supervised by Patrick Bösch and Pål Gisvold.
A. H. Grøvdal

Axel Hansen Grøvdal pursued his BSc degree at Department of Engineering Cybernetics during spring 2017, on a topic related to APT and glucose sensor calibration rig. Supervised by Patrick Bösch and Pål Gisvold.
 

Former students (alumni) in APT:

Listed here.

 


Contact: Sven M. Carlsen
Address: Dept. of Cancer Research and Molecular Medicine, NTNU, Olav Kyrres gate 10, NO-7491 Trondheim, Norway
E-mail: sven.carlsen@ntnu.no
Phone: +47 72571109
Mobile phone: +47 91769528

 
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